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Food and Agricultural Immunology Volume 34, 2023 - Issue 1
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Research Article

Protective mechanisms of intra- and extracellular polysaccharides from Schizophyllum commune on H2O2-induced oxidative damage of human skin fibroblasts

Wenjing Chenga College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
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Yundong Yanga College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
,
Jiachan Zhanga College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Fei qian Dia College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
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Luyao Lia College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
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Changtao Wanga College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
,
Meng Lia College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
,
Dan Zhaoa College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing, People’s Republic of China;b Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing, People’s Republic of China;c Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People’s Republic of China
,
Xiuqin Shid Yunnan Baiyao Group Co., Ltd., Kunming, People’s Republic of China
,
Tong Huod Yunnan Baiyao Group Co., Ltd., Kunming, People’s Republic of China
&
Quan And Yunnan Baiyao Group Co., Ltd., Kunming, People’s Republic of China
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Article: 2203407 | Received 31 Oct 2022, Accepted 11 Apr 2023, Published online: 29 May 2023
 
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ABSTRACT

Schizophyllum commune is a fungus with applications both in medicine and foods, which produces IPS and EPS. However, there is no comparative study on the activity comparison of IPS and EPS and its mechanism of antioxidant effect. In this study, the antioxidant activities of the two polysaccharides were measured in biochemical, cellular and molecular levels, and H2O2 induced oxidative damage model of HSFs was established to explore the protective effects of EPS and IPS. We found IPS and EPS both achieved a good antioxidant effect. They can also improve the cellular levels of SOD and reduce MDA. Insights regarding the molecular mechanism were studied, we found that both EPS and IPS could increase the expression of Nrf2 in Keap1-Nrf2/ARE signaling pathway. At the same time, they could inhibit the expression of the negative feedback gene Keap1 and promote the expression of downstream gene GCLC, Gstt-1, Nqo1 and Ho-1.

Acknowledgements

We are very grateful to our friends who helped us complete the manuscript and the associated financial support

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

JCZ, CTW, and QA provided concepts and designed experiments; WJC, YDY, LYL, and TH conducted experiments; FQD, DZ, XQS, and ML analysed data; WJC wrote the manuscript, JCZ, CTW read and commented on the first draft. All authors have read and approved the final manuscript.

Data availability statement

The data used and/or investigated during the present study are available from the corresponding author upon reasonable request.

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