In Vitro Biological Activity Screening of Arbutus Unedo Leaves in Light of Their Traditional Use

Ricardo Nunesa Food Science Laboratory, MED – Mediterranean Institute for Agriculture, Environment and Development & CHANGE – Global Change and Sustainability Institute, Faculty of Science and Technology, University of Algarve, Faro, PortugalView further author information

Isabel S. Carvalhoa Food Science Laboratory, MED – Mediterranean Institute for Agriculture, Environment and Development & CHANGE – Global Change and Sustainability Institute, Faculty of Science and Technology, University of Algarve, Faro, PortugalCorrespondence[email protected]
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Paweł Paśkob Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

Małgorzata Tyszka – Czocharab Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

Agnieszka Szewczykc Department of Pharmaceutical Botany, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

Marek Szlósarczykd Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

Irma Podolake Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

Agnieszka Galantye Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information

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ABSTRACT

The biological activity of A. unedo leaves, in relation to their traditional medicinal use in treating gastrointestinal and urinary tract diseases was verified. The ethanol extract of the leaves was quantitatively described in terms of flavonoids and phenolic acids (RP-HPLC), and zinc (voltametric analysis) and subjected to cytotoxic (MTT), antioxidant (TPC, TFC, TAA, RP, DPPH, and FRAP), antibacterial (disc diffusion), and antidiabetic assays (enzyme inhibition) in vitro. The extract was highly cytotoxic against prostate cancer cells, with less impact on colon carcinomas, while being nontoxic to normal prostate and kidney cells, and demonstrated antioxidant and antidiabetic activities.

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No potential conflict of interest was reported by the author(s).

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Funding

This work was supported by the Fundação para a Ciência e a Tecnologia of Portugal [SFRH/BDE/51888/2012].

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In Vitro Biological Activity Screening of Arbutus Unedo Leaves in Light of Their Traditional Use

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In Vitro Biological Activity Screening of Arbutus Unedo Leaves in Light of Their Traditional Use

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