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ABSTRACT
The impact of Origanum compactum essential oil (EO) at 80 mg kg−1 on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethics Approval
All experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.
Abbreviations
| AC | = | Atherogenic coefficient |
| CRI | = | Castelli’s risk index |
| EO | = | Essential oil |
| HDL-C | = | High-density lipoprotein cholesterol |
| HMG-CoA reductase | = | Hydroxymethyl-glutaryl coenzyme A reductase |
| LDL-C | = | Low-density lipoprotein cholesterol |
| TC | = | Total cholesterol |
| TGs | = | Triglycerides |
| VLDL-C | = | Very-low-density lipoprotein cholesterol |