Phytochemical profiling of Daemonorops acehensis Rustiami with different solvent extraction using LC-MS/MS and correlation with their antioxidant activity

ABSTRACT

One of the species that produces Jernang, a dragon blood resin that coats the rattan fruit used in traditional medicine, is Daemonorops acehensis. The extracts of Jernang from D. acehensis had an IC50 ranging from 52.40 ± 4.35 to 662.72 ± 37.86 mg/L. Metabolite profiling of the samples identified 31 metabolites, mainly from the phenolics group. The principal component analysis classified the jernang extracts with different extracting solvents, while the orthogonal partial least squares-discriminant predicted the antioxidant compound. We found nordracorhodin (1), dracorhodin (2), 2,4-dihydroxy-5-methyl-6-methoxychalcone (7), (2S)-5-methoxyflavan-7-ol (14), (2S)-5-methoxy-6-methylflavan-7-ol (17), and one unknown compound, contributed to the antioxidant activity of the sample.

KEYWORDS:

• Dragon blood resin
• flavonoids
• metabolomics
• UHPLC Q-Orbitrap HRMS

Acknowledgments

The authors gratefully acknowledge the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia for providing financial support for this study through the Penelitian Terapan Perguruan Tinggi 2022 (3722/IT3.L1/PT.01.03/P/B/2022).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi [Penelitian Terapan Perguruan Tinggi 2022].