Declaration of interest
M Ruscica has received a grant funded by the Fondazione Cariplo 2015 (2015-0552) and a Linea 2, Azione A intramural grant by the Universita delgi Studi di Milano. A Corsini has received fees for consulting and research funding from Amgen Innc, Sanofi Aventis, Pfizer Inc, Mediolanum, Merck Sharp and Dohme, Mylan and AstraZeneca.