Cytotoxicity sesquiterpenoids from the leaves of Datura stramonium L.

Abstract

Four new sesquiterpenoids, dstramonins A-D (1–4), and one new natural product (5), together with three known compounds (6–8), were isolated from the leaves of Datura stramonium L. The structures of new compounds were elucidated by extensive spectroscopic analysis and comparison with the literature. The cytotoxicity of isolates against LN229 cells was assessed and compounds 2–4, and 7 displayed cytotoxic activity with IC₅₀ values ranging from 8.03 to 13.83 μM.

Graphical Abstract

Keywords:

• Cytotoxicity
• Datura stramonium L.
• new natural compounds
• sesquiterpenoids

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NSFC) (82204596, 82104378), the Heilongjiang Touyan Innovation Team Program, and key research and development projects of Heilongjiang province (GA21D008).