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Abstract
Chemical investigation of a culture broth from the marine-derived fungus Pyrrhoderma noxium HNNU0524 yielded two new compounds including a drimane-type sesquiterpenoid named pyrrnoxin A (1) and a benzoic acid derivative, pyrrnoxin B (5), together with three related known analogues (2–4). The chemical structures of 1 and 5 were determined by detailed analysis of spectroscopic data, single-crystal X-ray crystallography, quantum mechanics-based DP4+ and ECD calculations. Compounds 2 and 3 moderately inhibited NO production of lipopolysaccharide-induced microglia cells BV2 with IC50 values of 26.6 and 60.5 µM, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Key Science and Technology Program of Hainan Province (No. ZDKJ202008), Natural Science Foundation of Hainan Province, China (220MS034), National Natural Science Foundation of China (41606100, 22177023, 41866005) and Innovation and Entrepreneurship Training Program for College Students (202111658002, S202111658006).