Glycosylated heterocyles emulsified with antifungal fraction of Moringa oleifera for potentiation of mycolytic activity

Abstract

To enhance the clinical effect of antifungal medications for treating deadly fungal infections there is an increasing demand for novel treatments. Exploration of multiple-drug targeting in antifungal therapeutics is the need of the present era. In this pursuit, we identified potent antifungal compounds that were directed towards the multiple virulent targets in Rhizopus arrhizus. Quinoxaline di-N-oxide and piperazine derivatives were identified to exhibit antifungal activities. 03 bioactive compounds were identified from the docking results and antifungal activity. Furthermore, these compounds which were combined with the alkaline extract of M. olifera to make the aqueous phase, an oil phase containing cinnamon oil or clove oil and a combination of surfactants was made to prepare a bioactive composite emulsion. A significant antimycotic activity was seen for the bioactive composite emulsion when compared with the clinically used antifungal drugs. Our results indicate the synergy and potentiation of antimycotic drugs based on integrative medicine.

Graphical Abstract

Keywords:

• Multitarget
• fungal infection
• Moringa oleifera
• emulsion

Acknowledgments

The authors are thankful to Dr. H. N. More, Principal, Bharati Vidyapeeth College of Pharmacy, Kolhapur, for providing the necessary facilities.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

No funding was received for this research.