Preparation and antibacterial activity of coronarin E derivatives

Abstract

Coronarin E is a main diterpene ever isolated from Hedychium yunnanense. With the aim to enlarge its potential application, four butenolide derivatives (compounds 4a, 4b, 5a and 5b) were obtained from coronarin E via synthetic method, and their antibacterial effects were also evaluated. It is noteworthy that compounds 5a and 5b exhibited stronger antibacterial activities against most of the tested bacterial strains than ampicillin and kanamycin, two first- and second-line antimicrobials in clinical. For example, minimum inhibitory concentration (MIC) of 5a, 5b, ampicillin and kanamycin against Acinetobacter baumanii were 2, 1, 8 and 4 μg/mL, respectively, and MIC of the four compounds mentioned above against Klebsiella pneumonia were 1, 0.5, 16 and 4 μg/mL, respectively. The current studies not only enrich the structural diversity of diterpenes derived from Hedychium genus, but also provide potent candidates for the development of antibacterial medicines.

GRAPHICAL ABSTRACT

Keywords:

• coronarin E
• furan-type diterpene
• synthetic derivatives
• antibacterial activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by the National Natural Sciences Foundation of China (82260687, 31960001, 81903476), and Yunnan Provincial Science and Technology Department-Yunnan University of Traditional Chinese Medicine Applied Basic Research Joint Special Fund Project (202101AZ070001-204), the Top Young Talents of Ten Thousand Program in Yunnan Province.