https://orcid.org/0000-0001-5573-6945
![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
ABSTRACT
The annual “Antibody Industrial Symposium”, co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28–29, 2022. The meeting focused on new results and concepts in antibody engineering (naked, mono- or multi-specific, conjugated to drugs or radioelements) and also on new cell-based therapies, such as chimeric antigenic receptor (CAR)-T cells. The symposium, which brought together scientists from academia and industry, also addressed issues concerning the production of these molecules and cells, and the necessary steps to ensure a strong intellectual property protection of these new molecules and approaches. These two days of exchanges allowed a rich discussion among the various actors in the field of therapeutic antibodies.
Disclosure statement
No potential conflict of interest was reported by the authors.
Abbreviations
| CAR | = | Chimeric Antigenic Receptor |
| AIS | = | Antibody Industrial Symposium |
| ADC | = | Antibody-Drug Conjugates |
| IP | = | Intellectual Property |
| TALEN | = | Transcription Activator-Like Effector Nucleases |
| FACS | = | Fluorescence-Activated Cell Sorting |
| PD-L1 | = | Programmed Death Ligand 1 |
| TEAM | = | T-Cell Engaging Antibody Molecule |
| STAb | = | Secretion of T Cell-Engaging Antibodies |
| AI | = | Artificial Intelligence |
| CODV | = | Cross-Over-Dual-Variable domain |
| NK | = | Natural Killer |
| EGFR | = | Epidermal Growth Factor Receptor |
| NKCE | = | NK Cell Engagers |
| ADCC | = | Antibody-Dependent Cellular Cytotoxicity |
| CDC | = | Complement-Dependent Cytotoxicity |
| AEMPS | = | Spanish Agency of Medicines and Medical Devices |
| ATMP | = | Advanced Therapy Medicinal Product |
| EU | = | European Union |
| EMA | = | European Medicines Agency |
| BCMA | = | B-Cell Maturation Antigen |
| TCR | = | T Cell Receptor |
| CAR-M | = | CAR Macrophage |
| APC | = | Antigen-Presenting Cells |
| IL-15 | = | Interleukin-15 |
| RA | = | Rheumatoid Arthritis |
| ACPA | = | Anti-Citrullinated Protein Antibodies |
| MS | = | Mass Spectrometry |
| CQA | = | Critical Quality Attributes |
| FDA | = | Food and Drug Administration |
| CIU | = | Collision Induced Unfolding |
| cCIU | = | cyclic CIU |
| HCD | = | High energy Collisional Dissociation |
| ETD | = | Electron-Transfer Dissociation |
| UVPD | = | UV Photo-Dissociation |
| PASEF | = | Parallel Accumulation and Serial Fragmentation |
| CE-MS | = | Capillary Electrophoresis hyphenated to MS |
| HCPs | = | Host Cell Proteins |
| LC | = | Liquid Chromatography |
| GMP | = | Good Manufacturing Practice |
| 2D-LC | = | Two-Dimensional Liquid Chromatography |
| ADA | = | Anti-Drug Antibodies |
| Tregitopes | = | T regulatory epitopes |
| DeFTs | = | Deimmunized Functional Therapeutics |
| AP | = | Alternative complement Pathway |
| CP | = | complement Classical Pathway |
| LP | = | complement Lectin Pathway |
| CMC | = | Chemistry, Manufacturing and Controls |
| INN | = | International Nonproprietary Names |
| WHO | = | World Health Organization |
| Ig | = | Immunoglobulin |
| BTN | = | Butyrophilin |
| MHC | = | Major-Histocompatibility-Complex |
| pAg | = | phosphoAntigen |
| UP | = | Unitary Patent |
| EP | = | European Patent |
| UPC | = | Unified Patent Court |
| MoA | = | Mechanisms of Action |
| CHIKV | = | CHIKungunya Virus |