The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

ABSTRACT

Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune evasion during viral transmission, thus imposing enormous challenges to avian health and poultry production. NDV is composed of six structural proteins and two nonstructural proteins that exert pivotal roles in viral infection and antiviral responses by interacting with host proteins. Nowadays, there is a particular focus on the mechanisms of virus-host protein interactions in NDV research, yet a comprehensive overview of such research is still lacking. Herein, we briefly summarize the mechanisms regarding the effects of virus-host protein interaction on viral infection, pathogenesis, and host immune responses. This review can not only enhance the present comprehension of the mechanism underlying NDV and host interplay, but also furnish a point of reference for the advancement of antiviral measures.

KEYWORDS:

• Newcastle disease virus
• viral proteins
• host proteins
• protein interaction
• pathogenesis
• host immune responses

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are openly available in the National Library of Medicine at https://www.ncbi.nlm.nih.gov/.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (31873021), by the National Natural Science Foundation of China (32302840), by the Earmarked Fund for China Agriculture Research System (CARS-40), by the 111 Project D18007 and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).