A narrative review of nonspecific effects of pediatric vaccines on child mortality and morbidity

ABSTRACT

We reviewed evidence on nonspecific effects of pediatric vaccines on mortality and morbidity in countries with high child mortality. Literature search of epidemiological studies was conducted for studies published between 2000 and September 2021 using MEDLINE. Consistent evidence exists regarding the potential protective effect of measles vaccine on child survival. Vaccination with Bacillus Calmette–Guérin (BCG) vaccine was related to lower risk of mortality in young children (including low birth weight babies) and inverse associations were found between developing a scar and having a positive tuberculin test after BCG vaccination with mortality. BCG vaccine might also reduce the risk of nontuberculosis infectious diseases. Studies on the association between diphtheria-pertussis-tetanus (DPT) vaccine and child survival showed inconsistent findings, which might be affected by bias and confounding. More evidence is needed to assess the role of these and other vaccines in children’s health and to better understand potential biological mechanisms and other influential factors.

KEYWORDS:

• Nonspecific effects
• vaccines
• children
• mortality
• morbidity

Acknowledgments

This work was undertaken in partial fulfillment of the requirements for a PhD degree of Ms. Muna Omar, at the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.