cis-Dioxomolybdenum(VI) complex of N-o-hydroxyacetophenonene-isonicotinic acid hydrazide as nosocomial anti-infectious agent: experimental and theoretical study

ABSTRACT

Due to growing resistance and continuous colonization among microbes, researchers are eager to design and put forth antibiotic substances of effective anti-nosocomial infection activity. Under such purview, the current report deals with synthesis and formulation of a dioxomolybdenum(VI) complex of general formula [MoO₂(L)(H₂O)], where H₂L = N-(o-hydroxyacetophenone)isonicotinic acid hydrazide (H₂haina), as antibiotic compound against hospital acquired infections. The complex was characterized by elemental analysis, conductance determination, magnetic susceptibility measurements, Proton Nuclear Magnetic reonance spectroscopy (¹HNMR), Fourier-transform Infra-red spectroscopy (FTIR), mass spectrometry, thermal and electronic spectral studies. Experimental data results were compared with theoretical outcomes by invoking density functional theory-based molecular topography and conjoint spectroscopic analysis with the help of Gaussian09 software package using LANL2DZ/B3LYP combination for the cis-dioxo group of distorted octahedral complex, [MoO₂(haina)(H₂O)]. The experimental and theoretical outcomes were found in an excellent agreement with one another. The overall study reveals that the complex under investigation possesses a cis-dioxo-octahedral geometry. Significant antimicrobial activity of the complex was obtained against hospital origin microbes in comparison with some selected standard commercial drugs including tetracycline and azithromycin. E. Coli and Pseudomonas were the microbes selected for the study.

KEYWORDS:

• cis-Dioxomolybdenum(VI); ¹HNMR
• NBO and HOMO–LUMO
• nosocomial

Acknowledgments

The authors are thankful to Prof. Kapil Deo Mishra, Vice Chancellor, Rani Durgavati University, Jabalpur, Madhya Pradesh, India for encouragement. Analytical facilities provided by the Central Drug Research Institute, Lucknow, India, and the Regional Sophisticated Instrumentation Centre, Indian Institute of Technology, Mumbai, India, are gratefully acknowledged.

Disclosure statement

No potential conflict of interest was reported by the authors.