Peroxisome proliferator-activated receptor-γ ligands as bone turnover modulators

Costas Giaginis University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75 Mikras Asias Street, Athens 11527, Greece. [email protected]; University of Athens, Department of Pharmaceutical Chemistry, School of Pharmacy, Panepistimiopolis, Zografou, Athens 157 71, Greece

Anna Tsantili-Kakoulidou University of Athens, Department of Pharmaceutical Chemistry, School of Pharmacy, Panepistimiopolis, Zografou, Athens 157 71, Greece

Stamatios Theocharis University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75 Mikras Asias Street, Athens 11527, Greece. [email protected]

Abstract

PPAR-γ ligands are being used for the treatment of human metabolic disorders; they also exert anti-inflammatory and antineoplastic properties that are now being explored in clinical studies. Recent data have further extended the crucial role of PPAR-γ and its ligands in bone turnover. This review summarises the latest knowledge of the expression of PPAR-γ in bone tissue and the regulatory effect of diverse synthetic and natural PPAR-γ ligands on bone formation and resorption. Taking into account the data so far, PPAR-γ ligands seem to be able to contribute to the treatment of various bone disorders including osteoporosis, as well as diabetic and age-related osteopoenia.

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Peroxisome proliferator-activated receptor-γ ligands as bone turnover modulators

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Peroxisome proliferator-activated receptor-γ ligands as bone turnover modulators

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