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Abstract
Importance of the field: The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however, its clinical relevance has not yet been established.
Areas covered in this review: We herein review the contribution of NHE-1 in atherogenesis (namely its effect on endothelial cells, monocytes, smooth muscle cells and platelets).
What the reader will gain: Studies have shown that NHE is involved in atherogenesis-related properties of isolated monocytes. We also consider the relationship between NHE-1 and vascular risk factors such as obesity, diabetes mellitus, hypertension, dyslipidemia and inflammation.
Take home message: Even though clinical trials with certain NHE-1 inhibitors have had discouraging results, NHE-1 cannot be excluded as a potential future therapeutic target for the prevention and/or treatment of atherosclerosis.
Acknowledgements
This paper is part of the 03ED29 research project implemented within the framework of the ‘Reinforcement Programme of Human Research Manpower’ (PENED) and co-financed by National and European Community Funds (25% from the Greek Ministry of Development - General Secretariat of Research and Technology and 75% from the EU - European Social Fund).
Notes
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