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Abstract
Pharmaceutical research on new anticancer drugs continues in two directions: a ‘prospective’ one involving the selection of compounds acting on ‘new’ biological targets; and a ‘conservative’ one involving the selection of chemotherapeutic agents acting on ‘validated’ targets. Clinical interest in paclitaxel (Taxol™) and docetaxel (Taxotere™) has led to a reactivation of research on agents that bind tubulin/microtubules. Several new antimitotic compounds were presented at the American Association for Cancer Research meeting in Toronto, last April.