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Abstract
A variety of approaches to investigate cell signalling were presented. The main goal of the speakers was to make use of signalling pathways as targets for the development of new drugs. These targets included protein kinase A anchoring, Ras-dependent transformation, growth factor receptor tyrosine kinases (trk and insulin), cytokine-mediated signalling, phospholipid lipases and immunosuppressant targeted enzymes. Each of the speakers gave a concise summary of the area involved and the rationale supporting their approaches to investigation.
Keywords
- anchoring proteins
- cancer
- cellular transformation
- diabetes mellitus
- farnesylation inhibitors
- geranylgeranylation inhibitors
- immunosuppressives
- mitogen-activated protein
- neurodegenerative diseases
- oncogenes
- phospholipases
- PI3-kinase related kinases
- protein kinases
- protein phosphatases
- protein tyrosine kinases
- small G proteins