Immunological manipulation of body composition

Abstract

Hormonal growth promoters (e.g., growth hormone [GH], β-adrenergic agonists, steroids), which improve growth rate and/or lean:fat ratios in the carcass, have received considerable adverse publicity and are either banned or have no licence for their use in the EC. This has led to the development of a number of techniques, involving the use of antibodies, aimed at regulating metabolic processes involved in determining growth and body composition. A different approach to the problem of excess fat deposition involves the use of antibodies directed against the plasma membranes of adipocytes in order to elicit their destruction and thereby limit the capacity for fat storage. This technique has been demonstrated in rats, sheep and pigs in both passive and active immunisation techniques. This promising approach is, however, limited by the lack of a commercially suitable vaccine. The identification of individual membrane proteins that are antigenic has been achieved and this affords the prospect of producing recombinant DNA-derived vaccines. Whether these new approaches will be perceived as acceptable to the general public remains a serious concern and a potential limitation to their development as many would-be sponsors withdraw their support for research in these areas.

• adipocyte
• antibody
• enhancement
• epitopes
• growth hormone
• obesity