Successful vaccination for Lyme disease:a novel mechanism

Abstract

Two vaccines are on the horizon for the prevention of Lyme disease, the most common vector-borne illness in the US and Europe. This review describes the pathogenesis and clinical illness of Lyme disease, as well as the sequence of events that led to the development of these novel vaccines. The results of the most recent Phase III human trials are reported.

• Borrelia burgdorferi
• Lyme disease
• OspA
• vaccine