Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery- a systematic review

Abstract

Background: Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil^® is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures. Objective: To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat. Methods: PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research. Results/conclusion: TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.

Keywords::

• collagen
• fibrin
• hemostat
• surgery
• TachoSil
• thrombin