A Case Report of Dyschromatosis Symmetrica Hereditaria with Glucose-6-Phosphate Dehydrogenase Deficiency

Abstract

Dyschromatosis symmetrica hereditaria (DSH) is a pigmented genetic skin disorder with an incompletely understood pathogenesis characterized by reticular hyper- and hypopigmented skin patches on the dorsal aspect of the extremities, freckle-like patches on the face, and unaffected palms and feet. There is no effective treatment available. Glucose-6-phosphate dehydrogenase (G6PD) deficiency has not been reported in the literature of DSH. We describe for the first time a case of DSH with G6PD deficiency and a family history of psychosis.

Keywords:

• dyschromatosis symmetrica hereditaria
• glucose-6-phosphate dehydrogenase deficiency
• psychosis
• ADAR1

Consent Statements

Written informed consent was provided by the patient and his parents to have the case details and any accompanying images published. Institutional approval was not required for this case study.

Acknowledgments

We thank the patient and his parents for their permission to publish this information.

Disclosure

The authors report no conflicts of interest in this work.