Blastic Plasmacytoid Dendritic Cell Neoplasm with Lung Involvement and Cytopenia: A Case Report and a Literature Review

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hostile cutaneous malignancy with dismal prognosis and unknown etiology with rarity. Most patients received traditional chemotherapy only has one year of median survival time. This article reports an 81-year-old male patient with BPDCN who presented with skin manifestations and was diagnosed with positive CD4, CD56, and CD123 immunohistochemical results. Systematic examination revealed lung involvement and cytopenia.

Keywords:

• blastic plasmacytoid dendritic cell neoplasm
• pathological feature
• lung involvement
• cytopenia
• treatment
• prognosis

Ethics Approval and Informed Consent

Written informed consent was signed by the patient’s daughter to approve publishing the case details and any accompanying images. Publication of the case details was approved by the ethical board of Beijing Chaoyang Hospital, Capital Medical University.

Acknowledgments

We thank the patient and physicians for participating in our study.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (Fund No. 82273551).