Successful Treatment of Psoriasis Combined with Bullous Pemphigoid with Dupilumab: A Case Report

Abstract

Psoriasis is an immune-mediated chronic inflammatory disease that can be combined with complications such as diabetes, cardiovascular disease, obesity, and kidney disease. The comorbidity of psoriasis with autoimmune bullous diseases (AIBD) has been reported previously in several cases, the most frequent of which is bullous pemphigoid (BP). The underlying mechanisms of psoriasis with BP are not clear and there are no uniform treatment criteria. Based on previous case reports, the coexistence of psoriasis and BP may be related to inflammatory activity, medications, phototherapy, and infection. We report a case of a psoriasis patient who developed BP after taking Chinese herbal compounds and was successfully treated with dupilumab, which is the first reported case of applying dupilumab to treat psoriasis with BP comorbidities.

Keywords:

• autoimmune bullous diseases
• dupilumab
• biologics
• comorbidity
• Chinese herbal compounds

Consent Statement

Informed consent was obtained from the patient for the publication of clinical information and related images. Institutional approval was not required to publish the case details.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

Hospital of Chengdu University of TCM Scientific Research Capacity Enhancement “Hundred Talents Program” (Grant No.20B04).