Treatment of the Nasolabial Fold Using a Hyaluronic Acid-Based Filler with eXcellent Three-Dimensional Reticulation (XTR™) Technology: A Retrospective Study

Abstract

Purpose

The physicochemical characteristics of hyaluronic acid (HA) fillers can affect the outcome of minimally invasive aesthetic treatments. The effect of a novel HA-based filler manufactured with a novel 3D structure (XTR^TM technology) was assessed in the nasolabial fold.

Patients and Methods

We performed a retrospective study of patients who underwent treatment of the nasolabial fold with a novel HA filler in our clinic. Treatment outcome was assessed at 3 and 6 months with wrinkle score, GAIS, and VAS.

Results

Eighteen patients were injected with the novel HA filler in the nasolabial fold. At six months, mean wrinkle scores were improved on both sides compared to baseline. GAIS and VAS were high at three and six months.

Conclusion

The HA-based filler manufactured with XTR^TM technology is safe and effective in treating the nasolabial fold. Good aesthetic results were seen for up to 6 months. Patient satisfaction was high during the entire follow-up.

Keywords:

• filler injection
• face rejuvenation
• monophasic
• crosslinking technology

Ethical Approval

The study was conducted according to the Declaration of Helsinki. The authors confirm that ethical approval from the local institutional review board is not required as the data presented refers to standard routine clinical practice without deviating from the instructions for use of the CE-marked medical device. All patients signed an informed consent form. Patients in Figures 1 and 2 gave written permission for image publication.

Acknowledgments

Editorial assistance was provided by ERA ms S.r.l. and funded by Relife S.r.l.

Disclosure

V.W. discloses personal fees (key opinion leader/speaker) from Relife. A. H. I. A. has nothing to disclose for this work.