https://orcid.org/0000-0003-2404-8415
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Abstract
Purpose
Verruciform xanthoma (VX) is a rare, chronic, and benign lesion affecting the skin and mucous membranes. We reported a case of VX in the vulva of a female child.
Patients and Methods
A 12-year-old female had vulvar lesions for over 10 years without any discomfort. Physical examination revealed red lobulated patches on the left labia majora with a few scales attached to the surface. Histopathological examination indicated excessive and incomplete keratinization, hypertrophic spinous layer hyperplasia, neutrophil infiltration in the epidermis, and foam-like tissue could be seen in the dermal papilla. Lymphocyte-dominated inflammatory cell infiltration was scattered around the blood vessels. Immunohistochemical results showed positive CD68.
Results
The final diagnosis confirmed the presence of VX.
Conclusion
Surgical intervention proved successful in achieving favorable outcomes for the patient.
Plain Language Summary
Verruciform xanthoma (VX) is a rare and non-cancerous skin condition that usually appears in the mouth but can occur on the genitals. In this case, a 12-year-old girl had red, warty lesions on her left labia majora for over 10 years. The cause of VX is not well understood but may be linked to inflammation, trauma, or immune disorders rather than lipid metabolism. The girl’s condition was confirmed through a biopsy, and she underwent surgical removal with no recurrence after a year. VX in the genital area is known as Vegas xanthomas. Though VX can look like other skin issues, a detailed examination of tissue samples is crucial for an accurate diagnosis. Treatment options include surgery, laser therapy, or topical creams. While VX is generally benign, seeking medical attention is important to rule out other concerns.
Abbreviations
VX, Verruciform xanthoma; CHILD, congenital hemidysplasia with ichthyosiform erythroderma and limb defects.
Ethics Statement
The publication of these pictures is subject to the consent of patients and their guardians and the signing of informed consent and approved by the Ethics Committee of Jiangxi Provincial Dermatology Hospital.
Consent Statement
The patient provided informed consent for the publication of the case.
Acknowledgments
These authors contributed equally to this work. Mei He and Mingqiang Liu are the first co-authors of this study.
Author Contributions
Meihua He and Mingqiang Liu are the first co-authors of this paper. All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors report no conflicts of interest in this work.