Etanercept Combined with Glucocorticoid and Gamma Globulin for Treating Children with Toxic Epidermal Necrolysis: A Case Report

Abstract

Toxic epidermal necrolysis (TEN) is a type of drug eruption in dermatology emergencies that is rare in clinical practice but has a high mortality rate. The main causes are drug and viral infections. Unfortunately, no expert consensus on treating this disease exists, and a standard therapy is absent. Up to now, glucocorticoids combined with gamma globulin are commonly used in clinical practice, but their efficacy is highly controversial. This study reports on a 7-year-old girl with TEN who did not respond to traditional therapy, such as methylprednisolone combined with gamma globulin, but was finally cured with an additional low-dose etanercept. The results showed that etanercept therapy in paediatric TEN is safe, reliable and worth recommending.

Keywords:

• child toxic epidermal necrolysis
• etanercept
• glucocorticoids
• gamma globulin

Data Sharing Statement

All data generated or analyzed during this study are included in this published article.

Ethics Approval and Consent to Participate

This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Baoding Hospital of Beijing Children’s Hospital. Written informed consent was obtained from parents/local guardians.

Consent for Publication

Written informed consent was obtained from parents/local guardians.

Disclosure

None of the authors have any personal, financial, commercial, or academic conflicts of interest.

Additional information

Funding

The authors have received no financial support for the research, authorship, or publication of this manuscript.