Surgical Treatment of Multiple Large Tuberous and Tendinous Xanthoma Secondary to Familial Hypercholesterolaemia: A Case Report

Abstract

Xanthomas are well-circumscribed skin lesions that are commonly seen in patients with familial hypercholesterolemia (FH). The aim of this report is to present a rare case of multiple large tuberous and tendinous xanthomas. A 17-year-old female patient in this report presented with multiple asymptomatic and papulo-nodular masses in both sides of palms, elbows, buttocks, knees, and Achilles tendons. Surgical removal of the masses was carried out in combination with lipid-lowering therapy. A following up of 3 months showed all wounds were healing well, and no recurrence of masses was observed. Therefore, for patients with xanthomas related with familial hypercholesterolaemia, lipid-lowering therapy has reportedly reduced the size of masses, but surgical treatment may be essential for large xanthomas caused pain or limitation of daily activities.

Keywords:

• soft-tissue tumors
• lipoprotein
• atorvastatin
• foam cells
• lipid-lowering therapy

Ethics Statement

No institutional approval is required for case reports, and the patient cannot be identified from the images.

Informed Consent Statement

Patient and her parents consented in writing for the publication of her case/photographs both online and in-print and understood that it will be publicly available and was sent a copy of the article to read.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This study was supported by Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality (Grant No. 22MC1940300).