Drug Reaction with Eosinophilia and Systemic Symptoms Induced by Diosmin and Hesperidin: A Case Report

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction which exhibits a diverse range of presentations. We described a 48-year-old man diagnosed with acute generalized exanthematous pustulosis (AGEP)-like DRESS following the administration of diosmin and hesperidin. To our knowledge, diosmin and hesperidin-induced DRESS are exceptionally rare. This aims to raise awareness of potential severe cutaneous side effects in patients taking these agents.

Keywords:

• chronic venous insufficiency
• daflon
• facial edema
• flavonoid
• severe cutaneous adverse reactions

Abbreviation

ADR, adverse drug reaction; AGEP, acute generalized exanthematous pustulosis; DRESS, Drug reaction with eosinophilia and systemic symptoms; ELISPOT, enzyme-linked immunospot; RegiSCARs, European Registry of Severe Cutaneous Adverse Reactions; SCARs, severe cutaneous adverse reactions.

Ethics Approval and Informed Consent

The authors certify that they have obtained all appropriate patient consent forms. The patient gave written informed consent for the publication of clinical information and photographs. Institutional approval was not required for this case details.

Disclosure

The authors declare that this manuscript was prepared in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Additional information

Funding

The authors received no financial support for this research.