High flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: an observational cohort study

Abstract

Background

High-flow nasal cannula (HFNC) oxygen therapy in acute hypoxic respiratory failure is becoming increasingly popular. However, evidence to support the use of HFNC in acute respiratory failure (ARF) with hypercapnia is limited.

Methods

Chronic obstructive pulmonary disease (COPD) patients with moderate hypercapnic ARF (arterial blood gas pH 7.25–7.35, PaCO₂>50 mmHg) who received HFNC or non-invasive ventilation (NIV) in the intensive care uint from April 2016 to March 2018 were analyzed retrospectively. The endpoint was treatment failure, defined as either invasive ventilation, or a switch to the other study treatment (NIV for patients in the NFNC group, and vice-versa), and 28-day mortality.

Results

Eighty-two COPD patients (39 in the HFNC group and 43 in the NIV group) were enrolled in this study. The mean age was 71.8±8.2 and 54 patients (65.9%) were male. The treatment failed in 11 out of 39 patients with HFNC (28.2%) and in 17 of 43 patients with NIV (39.5%) (P=0.268). No significant differences were found for 28-day mortality (15.4% in the HFNC group and 14% in the NIV group, P=0.824). During the first 24 hrs of treatment, the number of nursing airway care interventions in the HFNC group was significantly less than in the NIV group, while the duration of device application was significantly longer in the HFNC group (all P<0.05). Skin breakdown was significantly more common in the NIV group (20.9% vs 5.1%, P<0.05).

Conclusion

Among COPD patients with moderate hypercarbic ARF, the use of HFNC compared with NIV did not result in increased rates of treatment failure, while there were fewer nursing interventions and skin breakdown episodes reported in the HFNC group.

Keywords:

• chronic obstructive pulmonary diseases
• respiratory failure
• high-flow nasal cannula
• non-invasive ventilation
• cohort study

View correction statement:

High flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: an observational cohort study [Corrigendum]

Acknowledgments

We would like to thank Dr. Joseph Walline for proofreading assistance and reviewing the final manuscript. This work was supported by Rui E special fund for emergency medicine research (R2017003) and Yangzhou Science and Technology Development Plan (YZ2018090).

Abbreviation list

COPD, Chronic obstructive pulmonary disease; ARF, Acute respiratory failure; NIV, Non-invasive ventilation; HFNC, High-flow nasal cannula oxygen therapy; ICU, Intensive care unit; APACHE II, acute physiological and chronic health status score II; SAPS II, Simplified Acute Physiology Score II. PaCO₂, arterial carbon dioxide partial pressure; PaO₂, arterial oxygen partial pressure; FiO₂, fraction of inspired oxygen.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author in response to reasonable requests.

Disclosure

The authors declare that they have no competing interests in this work.