A Rare Case of Biliary Cryptococcosis Clinical Pharmacist Participation in Treatment and Pharmaceutical Care and Literature Review

Abstract

Biliary cryptococcosis infection is extremely rare and difficult for preoperative diagnosis. We report a rare case of 61-year-old woman with biliary cryptococcal infection. To explore the general rule and case characteristics of biliary cryptococcal infection and provide a reference for future diagnosis and treatment, we consulted the PubMed database for reported biliary cryptococcal infection from 1985 to 2021. Including the present one, we collected 12 reports, among which half were male and five were younger than 18 years old. Clinical manifestations were mainly jaundice, while in vitro examination revealed bile duct dilatation and bile duct stenosis. In 8 cases (66.67%), symptoms improved or healed after antifungal treatment. Although preoperative misdiagnosis of cryptococcal infection is high, the antifungal treatment is quite effective. Thus, early accurate diagnosis can effectively improve the cure rate of biliary cryptococcosis infected patients.

Keywords:

• biliary cryptococcosis
• obstructive jaundice
• Cryptococcus neoformans
• literature analysis

Data Sharing Statement

All data generated or analyzed during this study are included in this published article.

Consent Statement

Written informed consent was provided by the patient for the publication of the case details. Details of the case can be published without institutional approval.

Acknowledgments

This research was funded by the National Natural Science Foundation of China (grant Nos. 72074218).

Disclosure

The authors declare no conflicts of interest in this work.