Abstract
Purpose
This study aimed to determine the clinical profile connected to the nucleic acid conversion time of COVID-19 patients harboring the SARS-CoV-2 Omicron variant at the hospitals at the Fangcang shelter.
Methods
We reported 39,584 COVID-19 patients who were hospitalized in Shanghai, China, between April 5 and May 5, 2022, and who had contracted the Omicron strain of SARS-CoV-2. Demographic data, medical and vaccination history, clinical symptoms, and NCT were reported for the patient.
Results
The median age of the patients with COVID-19 included in this study was 45 (interquartile range [IQR]: 33–54), and 64.2% of them were male. The two most prevalent comorbidities among the patients were hypertension and diabetes. Additionally, we discovered that the percentage of unimmunized patients was negligible (13.2%). We found that male sex, age under 60, and other comorbidities including hypertension and diabetes are significant risk factors for extending NCT when we analyzed the risk variables for NCT. We discovered that vaccination with two or more doses can significantly reduce NCT. The analysis of the young (18–59 years) and older (60 years) populations produced the same outcomes.
Conclusion
Our findings confirm that a full COVID-19 vaccine series or booster doses are highly recommended to significantly reduce NCT. In order to reduce NCT, it is also advised that elderly people who have no clear contraindications take vaccination shots.
Abbreviations
COVID-19, coronavirus disease 2019; NCT, nucleic acid conversation time; SARS-COV-2, severe acute respiratory system coronavirus 2; IQR, Interquartile range; CKD, chronic kidney disease.
Data Sharing Statement
Data are available on request.
Ethics Approval and Consent to Participate
This study was authorized by the Ethics Commission for Clinical Research of Zhongda Hospital, affiliated with Southeast University (2022ZDSYLL190-P01). Informed consent was waived due to the nature of the study as a retrospective study. The study was conducted by the principles described in the Declaration of Helsinki and confidentiality of patients was guaranteed.
Acknowledgments
We thank Southeast University and Zhongda Hospital for their financial support.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, and interpretation, or all these areas; took part in drafting, revising, or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests.