Abstract
Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-generation sequencing (mNGS) results suggested Bartonella henselae. In addition, we obtained the whole genomic sequence of B. henselae ZJBH strain. To our knowledge, this is the first report of B. henselae genomic analysis isolated from clinic in China. Furthermore, we described the whole genome sequencing (WGS) data incorporating all B. henselae from diverse sources worldwide and shed light on underlying risk of B. henselae transmitted between cats and humans.
Abbreviations
IE, Infective endocarditis; mNGS, metagenomic next-generation sequencing; BCNE, blood-culture negative endocarditis; PCR, polymerase chain reaction; NCBI, National Center of Biotechnology Information; MLST, Multilocus sequence typing; WGS, whole genome sequencing.
Data Sharing Statement
The complete genome sequences of the B. henselae ZJBH reported here have been deposited at DDBJ/ENA/GenBank under accession no JARVXB000000000. The version described in this paper is the first version JARVXB000000000.
Ethics Approval and Consent for Publication
This case report was approved by Zhejiang Provincial People’s Hospital Research Ethics Board (QT2022429). This patient provided consent for publication of the clinical details, and written informed consent was obtained.
Disclosure
The authors declare that they have no competing interests in this work.