During the Omicron Pandemic Wave, the Severe Systemic Inflammatory Status of COVID-19 Indicated a Higher Risk of In-Hospital Mortality and Mediated the Clinical Efficacy of Corticosteroids

Abstract

Background

For the distinct immune/inflammatory responses from Omicron variant infection, this study aimed to investigate the diagnostic efficacy of systemic inflammatory indicators and the clinical efficacy of corticosteroids on the in-hospital mortality among COVID-19 patients.

Methods

Under a retrospective cohort study, 1081 COVID-19 patients were recruited from Beijing Youan Hospital, Capital Medical University between November 16, 2022 and January 30, 2023. We chose neutrophil-to-lymphocyte ratio (NLR), CRP-to-lymphocyte ratio (CLR), and CRP-to-albumin ratio (CAR) as the systemic inflammatory indicators. Receiver operating curve (ROC) and multivariate logistic regression analysis were used to determine the diagnostic efficacy of systemic inflammatory indicators and the association between systemic inflammatory indicators and in-hospital mortality.

Results

Among 684 patients included in analysis, 96 died during hospitalization. NLR, CLR and CAR performed well (with an area under the curve (AUC) greater than 0.75) in discriminating in-hospital mortality among COVID-19 patients. The severe status of systemic inflammation, with optimal cut-off value derived from ROC analysis, significantly associated higher risk of in-hospital mortality (OR = 3.81 for NLR ≥ 6.131; OR = 3.76 for CLR ≥ 45.455; OR = 5.10 for CAR ≥ 1.436). Corticosteroids use within 72 hours of admission increased the in-hospital mortality 2.88-fold for COVID-19 patients. In the subgroup of patients with severe systemic inflammation, corticosteroids increased the risk of in-hospital mortality (OR = 2.11 for NLR, p = 0.055; OR = 2.94 for CLR, p = 0.005; OR = 2.31 for CAR, p = 0.036).

Conclusion

Systemic inflammatory indicators had good diagnostic performance for in-hospital mortality. Patients with severe systemic inflammatory status should not receive corticosteroid treatment and further studies are warranted for confirmation.

Keywords:

• COVID-19
• systemic inflammatory indicators
• in-hospital mortality
• anti-inflammatory treatment

Ethics Approval

This study complied with the Helsinki Declaration for investigation of human subjects and was approved by the ethics committee of Beijing Youan Hospital, Capital Medical University (LL-2023-092-K). Informed consent was obtained from the participants.

Acknowledgments

This study was supported by Mr. Song Guo and Ms. Likun Yang from the Department of Internet, Beijing Youan Hospital, Capital Medical University.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This study was supported by Beijing Natural Science Foundation (L222120), High Level Public Health Technical Talents Construction Project from Beijing Municipal Health Commission (2022-2-025) and Bejing Hospital’s Authority (XMLX202114). The supporting organizations had no role in study design, data collection, analysis, and interpretation.