Age–Bilirubin–International Normalized Ratio (INR)–Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI

Abstract

Background

Given that age, international normalized ratio (INR), total bilirubin, and creatinine are reported to be independent risk factors for predicting outcome in patients with coronary artery disease (CAD), it is possible that the age–bilirubin–INR–creatinine (ABIC) score might be a potential prognostic model for patients with CAD.

Methods

A total of 6046 CAD patients after percutaneous coronary intervention (PCI) from the retrospective cohort study (Identifier: ChiCTR-ORC-16010153) were evaluated finally. The primary outcome long-term mortality and secondary endpoints mainly major adverse cardiovascular and cerebrovascular events (MACCEs) were recorded. Multivariate Cox regression models were used to determine risk factors for mortality and MACCEs.

Results

The ABIC score was significantly higher in the death group than in the survival group. After adjusting for other CAD risk factors, the ABIC score was identified to be an independent risk factor for long-term mortality by multivariate Cox analysis. When in the high ABIC group, the incidence of all-cause mortality would increased 1.7 times (adjusted HR=1.729 (1.347–2.218), P<0.001), and 1.5 times for cardiac death (adjusted HR=1.482 (1.126–1.951), P=0.005).

Conclusion

The present study indicated that ABIC score≥7.985 predicts high long-term mortality and cardiac death risk for PCI patients. The ABIC score might be a potential prognostic model for patients with PCI.

Keywords:

• age–bilirubin–international normalized ratio–creatinine score
• ABIC score
• coronary artery disease
• mortality
• prognosis

Data Sharing Statement

Data of this study were available from the corresponding author upon request.

Ethics Approval and Informed Consent

The ethics committee of the First Affiliated Hospital of Xinjiang Medical University approved the study protocol. The current study complies with the Helsinki Declaration. Due to the retrospective design of the study, the need to obtain informed consent from eligible patients was waived by the ethics committee. The privacy of the participants is maintained with confidentiality.

Consent to Publish

This manuscript has not been published or presented elsewhere in part or in entirety and is not under consideration by another journal. All authors agree to the publication of this work.

Author Contributions

T-TW and YP drafted the manuscript. Y-YZ and YY, designed the study and provided methodological expertise. X-GH and C-JD drafted the tables and figures and performed the statistical analysis. XX and Y-TM read and approved the final manuscript. All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that they have no competing interests for this work.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (grant No. 82170345).