https://orcid.org/0000-0001-9453-9346
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Abstract
Objective
The association between serum uric acid (sUA) and incident abdominal aortic calcification (AAC), and severe abdominal aortic calcification (SAAC) in the general population of the United States (US) is unclear. Therefore, this research aimed to investigate the association between sUA and the risk of AAC and SAAC.
Methods
Individuals from National Health and Nutrition Examination Survey (NHANES) database were analyzed cross-sectionally between 2013 and 2014. The restricted cubic spline (RCS), multivariable logistic regression model and subgroup analysis were utilized to evaluate the correlation between sUA and incident AAC, and SAAC. In addition, generalized additive models with smooth functions were employed to survey the relationship between sUA and the degree of AAC.
Results
This study included 3016 individuals from the NHANES database. According to the RCS plot, sUA levels were associated with the risk of AAC/SAAC in a U-shaped pattern in the US population. The degree of calcification decreased at first and then increased with the increase in the sUA level.
Conclusion
Close monitoring and adequate control of sUA levels in the US general population may reduce the risk of AAC and SAAC.
Data Sharing Statement
The datasets for this study can be found at www.cdc.gov/nchs/nhanes/.
Acknowledgments
The authors thank the staff and the participants of NHANES study for their valuable contributions.
Disclosure
The authors have declared no conflicts of interest.