The Emerging Roles of Pyroptosis, Necroptosis, and Ferroptosis in Non-Malignant Dermatoses: A Review

Abstract

Unlike apoptosis, pyroptosis, necroptosis, and ferroptosis are recently identified modes of programmed cell death (PCD) with unique molecular pathways. Increasing evidence has indicated that these PCD modes play a crucial role in the pathogenesis of various non-malignant dermatoses (a group of cutaneous disorders), including infective dermatoses, immune-related dermatoses, allergic dermatoses, benign proliferative dermatoses, etc. Moreover, their molecular mechanisms have been suggested as potential therapeutic targets for the prevention and treatment of these dermatoses. In this article, we aim to review and summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis and their roles in the pathogenesis of some non-malignant dermatoses.

Keywords:

• pyroptosis
• necroptosis
• ferroptosis
• molecular mechanisms
• non-malignant dermatoses

Disclosure

The authors declare that they have no conflicts of interest in this work.

Additional information

Funding

The research was supported by Zhejiang Medical and Health Science and Technology Project Youth Creative Talents Support Program (2022RC097) and the Outstanding Young People Fund in Zhejiang Provincial People’s Hospital (ZRY2020C008).