Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Abstract

Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes nigrum, Rosa rugosa, Agrostis stolonifera, Apocynum venetum and Nelumbo nucifera. This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure–activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound.

Keywords:

• hyperoside
• original plant
• chemical structure
• pharmacology
• pharmacokinetics
• toxicity

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This project is supported by a grant from the Chongqing Clinical Pharmacy Key Specialties Construction Project, Technology Project of Chongqing Health and Family Planning Commission (2019MSXM010) and Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxmX0223).