Effect of Hyperbaric Oxygen Intervention on Oxidative Stress and Expression of Nerve Growth Factor in Patients with Craniocerebral Injury

Abstract

Objective

To examine the impact of hyperbaric oxygen intervention on oxidative stress and nerve growth factor in patients with craniocerebral injury.

Methods

Using the random number table method, 40 patients with craniocerebral injury who were treated at the First People’s Hospital of Nantong were randomly assigned to either the control group or the hyperbaric oxygen group, with 20 patients in each group. The control group received routine intervention for clinical traumatic brain injury, while the hyperbaric oxygen group received additional hyperbaric oxygen intervention during the 7 to 30 days of routine intervention. Indicators of oxidative stress and nerve growth factor levels were compared between the two groups at the time of admission and 30 days after therapy.

Results

The serum levels of superoxide dismutase, endothelium-derived relaxing factor—nitric oxide, and nerve growth factor in the hyperbaric oxygen group increased more significantly than in the control group. The serum malondialdehyde concentration was also significantly reduced in the hyperbaric oxygen group.

Conclusion

Hyperbaric oxygen intervention can successfully lower systemic oxidative stress response and increase the expression level of nerve growth factor in patients with craniocerebral injury.

Keywords:

• craniocerebral injury
• hyperbaric oxygen
• nerve growth factor
• oxidative stress

Abbreviations

SOD, superoxide dismutase; NO, nitric oxide; NGF, nerve growth factor; MDA, Malondialdehyde; HBO, hyperbaric oxygen; TBI, Traumatic brain injury; GCS, Glasgow coma scale; BBB, blood-brain barrier.

Data Sharing Statement

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.

Ethics Approval and Consent to Participate

This study was conducted with approval from the Ethics Committee of the Nantong First People’s Hospital (2018KT096). This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants.

Acknowledgments

We would like to acknowledge the hard and dedicated work of all the staff that implemented the intervention and evaluation components of the study.

Disclosure

The authors declare that they have no competing interests in this work.

Additional information

Funding

1. Natural Science Project of Nantong Science and Technology Bureau (No. JC2021182); 2. Jiangsu Provincial Health Care Commission Guidance Project (No. Z2021017); 3. Nantong Municipal Health Commission Subjects (QN2023009 and QN2023012).