Serum Mrp 8/14 as a Potential Biomarker for Predicting the Occurrence of Acute Respiratory Distress Syndrome Induced by Sepsis: A Retrospective Controlled Study

Abstract

Background

To date, there are no studies regarding the Mrp 8/14 in predicting the occurrence of acute respiratory distress syndrome (ARDS) induced by sepsis. Thus, the objective of this study was to investigate the expression of Myeloid-related proteins 8 and 14 (Mrp 8/14) and its role in ARDS induced by sepsis.

Methods

A total of 168 septic patients were enrolled in the observational study. The baseline information and clinical outcomes were obtained retrospectively. Serum Mrp 8/14 level was determined by enzyme linked immunosorbent assay (ELISA). The patients were categorized into sepsis and ARDS group based on whether they developed ARDS during the intensive care unit (ICU) hospitalization.

Results

There was significant difference in the level of Mrp 8/14 between the sepsis group and ARDS groups (P < 0.05). Mrp 8/14 correlated positively with procalcitonin (PCT), interleukin-6 (IL-6), acute physiology and chronic health evaluation II (APACHE II) score, sequential organ failure assessment (SOFA) score on day 1, mechanical ventilation time, length of ICU stay and hospitalization expenses in ICU (all P < 0.05). Logistic regression analysis showed Mrp 8/14 was the independent factor for forecasting the occurrence of sepsis- induced ARDS (P < 0.05). The areas under receiver operating characteristic curves for Mrp 8/14 were higher than that of PCT, APACHE II score and SOFA score on day 1 (P < 0.05).

Conclusion

The serum Mrp 8/14 level at admission may be a potential marker for predicting the occurrence of ARDS induced by sepsis. Early detection of serum Mrp 8/14 could help clinicians to identify and evaluate the severity of ARDS induced by sepsis.

Keywords:

• sepsis
• acute respiratory distress syndrome
• Mrp 8/14
• inflammation
• intensive care unit

Abbreviations

APACHE II score, Acute physiology and chronic health evaluation II score; WBC, White blood cell; PCT, Procalcitonin; SOFA score, Sequential Organ Failure Assessment score; IL-6, Interleukin-6; Bun, Blood urea nitrogen; Mrp 8/14, Myeloid-related proteins 8 and 14; ARDS, Acute respiratory distress syndrome; COPD, Chronic obstructive pulmonary disease; S100 A8/A9, Calprotectin or S100 calcium-binding protein A8 and A9; LPS, Lipopolysaccharide; COVID-19, Corona-virus disease 2019.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This work was supported by Nanjing Medical Science and Technique Development Foundation Project (YKK22115, YKK20114).