Characteristics of the Attentional Network in Children with Sleep-Disordered Breathing

Abstract

Purpose

To explore the characteristics of the attentional network and related factors in children with sleep-disordered breathing (SDB).

Patients and Methods

A total 228 children (200 children aged 6–10 years with snoring or mouth breathing, admitted to our hospital from May 2020 to July 2022, and 28 healthy children recruited from the community as the control group) were enrolled. All participants underwent polysomnography (PSG) and completed the ADHD rating scale and child version of the Attention Network Test. According to their SDB history and obstructive apnea hypopnea index (OAHI), the participants were divided into control (n = 28), primary snoring (PS; n = 67) and obstructive sleep apnea (OSA; n = 133) groups.

Results

The OSA and PS groups were younger than controls (P < 0.05). The proportion of boys was higher in the OSA than control group (P < 0.05). Body mass index was higher in the OSA than control and PS groups (P < 0.01). Attention deficit and hyperactive impulsivity scores were independently associated with the OAHI (P < 0.001). The efficiency of the alerting network was higher in the OSA than in controls (P = 0.020), but was not correlated with OAHI after adjusting for age, sex and SDB history duration (P > 0.05).

Conclusion

Children with OSA have impaired attention, characterized by excessive alerting network activation. However, alerting network efficiency did not change linearly with disease severity. More research is needed to elucidate the neural mechanisms underlying attention deficits in pediatric OSA.

Keywords:

• child
• obstructive sleep apnea
• attention
• alerting network

Acknowledgments

This study was supported by Beijing Natural Science Foundation [7212033], National Natural Science Foundation of China [82070092], the Fundamental Research Funds for the Central Universities [2242022k30036], the Fundamental Research Funds for the central Universities [2242022k30037] and National Clinical Research Center for Respiratory Diseases (HXZX-20210401).

Disclosure

The authors report no conflicts of interest in this work.