Noninvasive imaging modalities in coronary artery disease: a meta analysis comparing coronary computed tomography angiography and standard of care

Abstract

Introduction: Coronary artery disease has become a global pandemic and a major cause of death. The risk-factor calculation for coronary artery damage is an invasive procedure. Aim: To compare coronary computed tomography angiography (CCTA) with standard of care (SOC) to calculate need for revascularization, invasive coronary angiography as well as for myocardial infarction (MI) incidence and all-cause mortality. Methodology, results & conclusion: CCTA is significantly correlated with a reduction in MI episodes (RR = 0.752, 95% CI = 0.578–1.409; p < 0.033) and an increase in revascularizations (RR = 1.401, 95% CI = 1.315–1.492; p < 0.001) and invasive coronary angiography procedures (RR = 1.304, 95% CI = 1.208–1.409; p < 0.001). However, it was found that it did not affect all-cause mortality. On the contrary, standard care approaches were associated with greater rates of MI but lesser referrals for invasive coronary angiography and revascularization.

Keywords: :

• acute coronary syndrome
• all-cause mortality
• CCTA
• coronary angiography
• coronary artery disease
• myocardial infarction
• revascularization
• SOC

Author contributions

A Dani and D Desai conceived the idea and designed the analysis; A Dani and P Shah collected the data; P Shah, A Dani & D Desai contributed data or analysis tools; D Desai performed the analysis; P Shah & A Dani wrote the paper.

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.