Long Noncoding RNA Polymorphisms in Gynecological Cancers

Abstract

Gynecological malignancies are one of the main causes of cancer-induced mortality. Despite remarkable recent therapeutic advances, current therapeutic options are not sufficient. Regarding the effect of long noncoding RNAs (lncRNAs) on cell differentiation, proliferation and apoptosis, variations in their expression cause different anomalies, such as tumorigenesis. SNPs influence lncRNA function and expression. LncRNA polymorphisms can predict cancer risk and are effective for early diagnosis and customized therapy. In this literature review, we comprehensively investigate the effect of lncRNA polymorphisms on gynecological cancers. LncRNA-related variants are proposed to evaluate cancer incidence, early detection and management of personalized therapy. Nonetheless, more studies are required to validate the consistency of current findings in numerous samples and across various ethnic groups.

Keywords::

• cancer risk
• cervical cancer
• endometrial cancer
• genotype
• gynecological cancers
• lncRNA
• ovarian cancer
• personalized therapy
• SNP

Author contributions

All authors participated in the design, interpretation of the studies and analysis of the data and review of the manuscript; S Latifi-Navid, E Abdi and A Panahi provided direction in the preparation of the manuscript and performed primary literature search. E Abdi, S Latifi-Navid and A Panahi wrote the first draft of manuscript and discussed and revised the manuscript. E Abdi and S Latifi-Navid managed the references.

Financial disclosure

The National Institute for Medical Research Development (NIMAD; grant number 958117), Tehran, Iran. The supporter had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The National Institute for Medical Research Development (NIMAD; grant number 958117), Tehran, Iran. The supporter had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.