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Drug Evaluations

Diflomotecan, a promising homocamptothecin for cancer therapy

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Pages 69-75 | Published online: 21 Nov 2008

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Jing Zhang, Shijie Zhang, Zhipeng Sun, Yu Cai, Guohua Zhong & Xin Yi. (2023) Camptothecin Effectively Regulates Germline Differentiation through Bam–Cyclin A Axis in Drosophila melanogaster. International Journal of Molecular Sciences 24:2, pages 1617.
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Valeriy A. Bacherikov. (2022) Total Synthesis, Mechanism of Action, and Antitumor Efficacy of Camptothecin and Some of its Analogues. Anti-Cancer Agents in Medicinal Chemistry 22:20, pages 3438-3465.
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A.G. Nerkar, G.S. Chakraborthy & R. D. Ukirde. (2021) Anti-cancer agents from natural sources: A review. Current Trends in Pharmacy and Pharmaceutical Chemistry 3:4, pages 38-46.
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Ruo-Jun Man, Nasreen Jeelani, Chongchen Zhou & Yu-Shun Yang. (2021) Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry 21:7, pages 825-838.
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T. Pullaiah & V. Raveendran. 2020. Camptothecin and Camptothecin Producing Plants. Camptothecin and Camptothecin Producing Plants 47 103 .
Zhiyan Xiao, Susan L. Morris-Natschke & Kuo-Hsiung Lee. (2016) Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews 36:1, pages 32-91.
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Yang Xu & Chengtao Her. (2015) Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy. Biomolecules 5:3, pages 1652-1670.
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Giuseppe Giannini. 2014. Natural Products in Medicinal Chemistry. Natural Products in Medicinal Chemistry 181 224 .
Qingqing Huang, Lei Wang & Wei Lu. (2013) Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European Journal of Medicinal Chemistry 63, pages 746-757.
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W.A. Denny. 2013. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
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Julia Moukharskaya & Claire Verschraegen. (2012) Topoisomerase 1 Inhibitors and Cancer Therapy. Hematology/Oncology Clinics of North America 26:3, pages 507-525.
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Beverly A. Teicher. 2012. DNA Topoisomerases and Cancer. DNA Topoisomerases and Cancer 185 210 .
David Cragg, Gordon Kingston & David NewmanNicolas Rahier, Craig Thomas & Sidney Hecht. 2011. Anticancer Agents from Natural Products, Second Edition. Anticancer Agents from Natural Products, Second Edition 5 26 .
Bhuwan B. Mishra & Vinod K. Tiwari. (2011) Natural products: An evolving role in future drug discovery. European Journal of Medicinal Chemistry 46:10, pages 4769-4807.
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Thomas S. Dexheimer, Lalji K. Gediya, Andrew G. Stephen, Iwona Weidlich, Smitha Antony, Christophe Marchand, Heidrun InterthalMarc Nicklaus, Robert J. Fisher, Vincent C. Njar & Yves Pommier. (2009) 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and Related Novel Steroid Derivatives as Tyrosyl-DNA Phosphodiesterase (Tdp1) Inhibitors. Journal of Medicinal Chemistry 52:22, pages 7122-7131.
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