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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 2
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Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials

Jesus A Gonzalo Asensio University of Zaragoza, Department of Microbiology, Spain
, PhD,
Ainhoa Arbués University of Zaragoza, Department of Microbiology, Spain
,
Esther Pérez University of Zaragoza, Department of Microbiology, Spain; GSK I+D DDW, GlaxoSmithKline, Parque Tecnológico de Madrid, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain
, PhD,
Brigitte Gicquel Unité Génetique Mycobactérienne, Institut Pasteur Paris, France
, PhD &
Carlos Martin Universidad de Zaragoza, Grupo de Genetica de Micobacterias, CIBER Enfermedades Respiratorias, Departamento de Microbiologia, Facultad de Medicina, C/Domingo Miral sn, 50009 Zaragoza, Spain +34 976 76 17 59; +34 976 76 16 64; [email protected]
, MD PhD
Pages 201-211 | Published online: 14 Jan 2008

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Pramod K Giri. (2008) How could we have better vaccines against tuberculosis?. Expert Opinion on Biological Therapy 8:11, pages 1759-1772.
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Mi Huang, Mafeng Liu, Jiajun Liu, Mingshu Wang, Renyong Jia, Dekang Zhu, Shun Chen, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Qun Gao, Juan Huang, Xumin Ou, Sai Mao, Bin Tian, Di Sun & Anchun Cheng. (2023) Evaluation of the immunoprotection efficacy of Riemerella anatipestifer fur-deficient mutant as an attenuated vaccine. Poultry Science 102:3, pages 102450.
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Moses GalukandeLeonard Francis WereJoanita KigoziCarol KahendekeAlex MuganziAndrew Kambugu. (2020) Closing the Gap toward Zero Tetanus Infection for Voluntary Medical Male Circumcision: Seven Case Reports and a Review of the Literature. Surgical Infections 21:7, pages 599-607.
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Abdallah M. Abdallah, Eveline M. Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A. Adroub, Tareq B. Malas, Raeece Naeem, Huoming Zhang, Thomas D. Otto, Wilbert Bitter & Arnab Pain. (2019) Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. PLOS ONE 14:1, pages e0211003.
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Aurobind Vidyarthi, Nargis Khan, Tapan Agnihotri, Kaneez F. Siddiqui, Girish R. Nair, Ashish Arora, Ashok K. Janmeja & Javed N. Agrewala. (2017) Antibody response against PhoP efficiently discriminates among healthy individuals, tuberculosis patients and their contacts. PLOS ONE 12:3, pages e0173769.
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Kishore Das, Tima Thomas, Omar Garnica & Subramanian Dhandayuthapani. (2016) Recombinant Bacillus subtilis spores for the delivery of Mycobacterium tuberculosis Ag85B-CFP10 secretory antigens. Tuberculosis 101, pages S18-S27.
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Aditi Sharma, Tige Rustad, Gaurang Mahajan, Arun Kumar, Kanury V.S. Rao, Sharmistha Banerjee, David R. Sherman & Shekhar C. Mande. (2016) Towards understanding the biological function of the unusual chaperonin Cpn60.1 (GroEL1) of Mycobacterium tuberculosis. Tuberculosis 97, pages 137-146.
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Xinxin Zhao, Qing Liu, Jie Zhang, Yali Luo, Ying Luo, Qiong Liu, Pei Li & Qingke Kong. (2016) Identification of a gene in Riemerella anatipestifer CH-1 (B739-2187) that contributes to resistance to polymyxin B and evaluation of its mutant as a live attenuated vaccine. Microbial Pathogenesis 91, pages 99-106.
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Daria Bottai, Timothy P. Stinear, Philip Supply & Roland Brosch. 2014. Molecular Genetics of Mycobacteria. Molecular Genetics of Mycobacteria 27 47 .
Tanya Parish. 2014. Molecular Genetics of Mycobacteria. Molecular Genetics of Mycobacteria 209 223 .
Peter Davies, Stephen Gordon & Geraint DaviesHelen McShane. 2014. Clinical Tuberculosis, Fifth Edition. Clinical Tuberculosis, Fifth Edition 339 350 .
Daria Bottai, Timothy P. Stinear, Philip Supply & Roland Brosch. (2014) Mycobacterial Pathogenomics and Evolution. Microbiology Spectrum 2:1.
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Tanya Parish. (2014) Two-Component Regulatory Systems of Mycobacteria. Microbiology Spectrum 2:1.
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Dorsaf Hedhli, Olivier Denis, Daniel Barkan, Mamadou Daffé, Michael S. Glickman & Kris Huygen. (2013) M.tuberculosis Mutants Lacking Oxygenated Mycolates Show Increased Immunogenicity and Protective Efficacy as Compared to M. bovis BCG Vaccine in an Experimental Mouse Model. PLoS ONE 8:10, pages e76442.
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Federico Carlos Blanco, María Verónica Bianco, Sergio Garbaccio, Virginia Meikle, María José Gravisaco, Valeria Montenegro, Edgar Alfonseca, Mahavir Singh, Soledad Barandiaran, Ana Canal, Lucas Vagnoni, Bryce Malcom Buddle, Fabiana Bigi & Angel Cataldi. (2013) Mycobacterium bovis Δmce2 double deletion mutant protects cattle against challenge with virulent M. bovis. Tuberculosis 93:3, pages 363-372.
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Jonathan M. Pitt, Simon Blankley, Helen McShane & Anne O'Garra. (2013) Vaccination against tuberculosis: How can we better BCG?. Microbial Pathogenesis 58, pages 2-16.
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Stefan H.E. Kaufmann. (2012) Tuberculosis vaccine development: strength lies in tenacity. Trends in Immunology 33:7, pages 373-379.
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Sankaralingam Saikolappan, Jaymie Estrella, Smitha J. Sasindran, Arshad Khan, Lisa Y. Armitige, Chinnaswamy Jagannath & Subramanian Dhandayuthapani. (2012) The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages. PLoS ONE 7:5, pages e36198.
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Jonathan K. Nambiar, Rachel Pinto, Juan I. Aguilo, Kiyoshi Takatsu, Carlos Martin, Warwick J. Britton & James A. Triccas. (2011) Protective immunity afforded by attenuated, PhoP ‐ deficient Mycobacterium tuberculosis is associated with sustained generation of CD4 + T‐cell memory . European Journal of Immunology 42:2, pages 385-392.
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Virgilio Bocanegra-García, Jorge Valencia-Delgadillo, Wendy Cruz-Pulido, Rubén Cantú-Ramírez, Gildardo Rivera-Sánchez & José Prisco Palma-Nicolás. (2011) De la genética a la genómica en el diseño de nuevas vacunas contra la tuberculosis. Enfermedades Infecciosas y Microbiología Clínica 29:8, pages 609-614.
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Stefan HE Kaufmann. (2011) Fact and fiction in tuberculosis vaccine research: 10 years later. The Lancet Infectious Diseases 11:8, pages 633-640.
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Andrés Obregón-Henao, Crystal Shanley, María Verónica Bianco, Angel A. Cataldi, Randall J. Basaraba, Ian M. Orme & Fabiana Bigi. (2011) Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis. Vaccine 29:26, pages 4302-4307.
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Mei M. Ho, James Southern, Hye-Na Kang & Ivana Knezevic. (2010) WHO Informal Consultation on standardization and evaluation of BCG vaccines Geneva, Switzerland 22–23 September 2009. Vaccine 28:43, pages 6945-6950.
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Shreemanta K Parida & Stefan HE Kaufmann. (2010) Novel tuberculosis vaccines on the horizon. Current Opinion in Immunology 22:3, pages 374-384.
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K.B. Walker, M.J. Brennan, M.M. Ho, J. Eskola, G. Thiry, J. Sadoff, R. Dobbelaer, L. Grode, M.A. Liu, U. Fruth & P.H. Lambert. (2010) The second Geneva Consensus: Recommendations for novel live TB vaccines. Vaccine 28:11, pages 2259-2270.
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Jesus Gonzalo Asensio, Ainhoa Arbues, Dessi Marinova & Carlos Martín. (2010) Uma nova vacina viva contra a tuberculose com base na inativação do phoP. Revista Portuguesa de Pneumologia 16, pages S43-S48.
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Susanne Gola, Riccardo Manganelli, María Jesús García & Miguel Vicente. (2009) News from the antituberculosis front at two recent European meetings. World Journal of Microbiology and Biotechnology 25:7, pages 1129-1143.
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Frank A. W. Verreck, Richard A. W. Vervenne, Ivanela Kondova, Klaas W. van Kralingen, Edmond J. Remarque, Gerco Braskamp, Nicole M. van der Werff, Ariena Kersbergen, Tom H. M. Ottenhoff, Peter J. Heidt, Sarah C. Gilbert, Brigitte Gicquel, Adrian V. S. Hill, Carlos Martin, Helen McShane & Alan W. Thomas. (2009) MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques. PLoS ONE 4:4, pages e5264.
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P.J. Cardona, J. Gonzalo Asensio, A. Arbués, I. Otal, C. Lafoz, O. Gil, N. Caceres, V. Ausina, B. Gicquel & C. Martin. (2009) Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant. Vaccine 27:18, pages 2499-2505.
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G.M. Scandurra, M. Young, G.W. de Lisle & D.M. Collins. (2009) A bovine macrophage screening system for identifying attenuated transposon mutants of Mycobacterium avium subsp. paratuberculosis with vaccine potential. Journal of Microbiological Methods 77:1, pages 58-62.
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Andrea S Leung, Vanessa Tran, Zuowei Wu, Xuping Yu, David C Alexander, George Fu Gao, Baoli Zhu & Jun Liu. (2008) Novel genome polymorphisms in BCG vaccine strains and impact on efficacy. BMC Genomics 9:1.
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Jesús Gonzalo-Asensio, Carlos Y. Soto, Ainhoa Arbués, Javier Sancho, María del Carmen Menéndez, María J. García, Brigitte Gicquel & Carlos Martín. (2008) The Mycobacterium tuberculosis phoPR Operon Is Positively Autoregulated in the Virulent Strain H37Rv . Journal of Bacteriology 190:21, pages 7068-7078.
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Jesús Gonzalo-Asensio, Serge Mostowy, Jose Harders-Westerveen, Kris Huygen, Rogelio Hernández-Pando, Jelle Thole, Marcel Behr, Brigitte Gicquel & Carlos Martín. (2008) PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence. PLoS ONE 3:10, pages e3496.
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Ying ZHANG. (2008) Immunopathogenesis of tuberculosis: Implications for vaccine development. Respirology 13, pages S81-S87.
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