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Human drug hepatotoxicity: a contemporary clinical perspective

, MD & , MD
Pages 463-473 | Published online: 06 May 2009

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Akifumi Kogame, Ronald Lee, Liping Pan, Miyako Sudo, Masami Nonaka, Yuu Moriya, Tomoaki Higuchi & Yoshihiko Tagawa. (2019) Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica 49:4, pages 433-445.
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Articles from other publishers (33)

Hui Zhang, Hong-Rui Zhang, Mei-Ling Hu & Hua-Zhao Qi. (2022) Development of binary classification models for assessment of drug-induced liver injury in humans using a large set of FDA-approved drugs. Journal of Pharmacological and Toxicological Methods 116, pages 107185.
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Safa Moussaoui, Mehdi Abdelwahed, Nabil Ben Chaaben, Ahlem Bellalah, Najah Ben Fadhel, Arwa Guediche, Mejda Zakhama, Ramzi Tababi, Karim Aouam, Zakhama Abdelfattah, Hichem Loghmari & Leila Safer. (2022) Norethisterone‐induced cholestasis: A case report. Clinical Case Reports 10:3.
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Elliot Freeman & Stuart K Roberts. (2021) Drug‐induced liver injury caused by herbal and dietary supplements: where to next?. Medical Journal of Australia 215:6, pages 259-260.
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Keerthana Jaganathan, Hilal Tayara & Kil To Chong. (2021) Prediction of Drug-Induced Liver Toxicity Using SVM and Optimal Descriptor Sets. International Journal of Molecular Sciences 22:15, pages 8073.
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Manuela G. Neuman. 2020. Liver Diseases. Liver Diseases 75 84 .
Vladimir R. Vukic, Davor M. Loncar, Dajana V. Vukic, Lidija R. Jevric, Goran Benedekovic, Jovana Francuz, Vesna Kojic, Milica Z. Karadzic Banjac & Velimir Popsavin. (2019) In vitro antitumor activity, ADME-Tox and 3D-QSAR of synthesized and selected natural styryl lactones. Computational Biology and Chemistry 83, pages 107112.
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Shuaibing He, Tianyuan Ye, Ruiying Wang, Chenyang Zhang, Xuelian Zhang, Guibo Sun & Xiaobo Sun. (2019) An In Silico Model for Predicting Drug-Induced Hepatotoxicity. International Journal of Molecular Sciences 20:8, pages 1897.
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Manuela G. Neuman. (2019) Biomarkers of Drug-Induced Liver Toxicity. Therapeutic Drug Monitoring 41:2, pages 227-234.
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N.M. Bubalo & G.M. Balan. (2018) Syndrome of intrahepatic cholestasis in patients with acute and chronic intoxication with pesticides. Ukrainian Journal of Modern Toxicological Aspects 81:1, pages 39-48.
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Jing Jing & Rolf Teschke. (2018) Traditional Chinese Medicine and Herb-induced Liver Injury: Comparison with Drug-induced Liver Injury. Journal of Clinical and Translational Hepatology 6:1, pages 1-12.
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Patric Schyman, Ruifeng Liu, Valmik Desai & Anders Wallqvist. (2017) vNN Web Server for ADMET Predictions. Frontiers in Pharmacology 8.
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Garrett B. Goh, Nathan O. Hodas & Abhinav Vishnu. (2017) Deep learning for computational chemistry. Journal of Computational Chemistry 38:16, pages 1291-1307.
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Chetan Rathi, Nirav Pipaliya, Ruchir Patel, Meghraj Ingle, Aniruddha Phadke & Prabha Sawant. (2017) Drug Induced Liver Injury at a Tertiary Hospital in India: Etiology, Clinical Features and Predictors of Mortality. Annals of Hepatology 16:3, pages 442-450.
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Hui Zhang, Lan Ding, Yi Zou, Shui-Qing Hu, Hai-Guo Huang, Wei-Bao Kong & Ji Zhang. (2016) Predicting drug-induced liver injury in human with Naïve Bayes classifier approach. Journal of Computer-Aided Molecular Design 30:10, pages 889-898.
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Richard A. Thompson, Emre M. Isin, Monday O. Ogese, Jerome T. Mettetal & Dominic P. Williams. (2016) Reactive Metabolites: Current and Emerging Risk and Hazard Assessments. Chemical Research in Toxicology 29:4, pages 505-533.
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Hyeyoung Cho, Hyosil Kim, Dokyun Na, So Youn Kim, Deokyeon Jo & Doheon Lee. (2016) Meta-analysis method for discovering reliable biomarkers by integrating statistical and biological approaches: An application to liver toxicity. Biochemical and Biophysical Research Communications 471:2, pages 274-281.
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Hyun-Kyu ParkWoori JoHyun-Ji ChoiSungwoong JangJae-Eun RyuHyo-Ju LeeHyojin LeeHyejin KimEun-Sil YuWoo-Chan Son. (2016) Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats. Journal of Veterinary Science 17:1, pages 45.
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Zanelle Bekker, Andrew Walubo & Jan B. Du Plessis. (2016) Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats. Advances in Pharmacological Sciences 2016, pages 1-12.
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J.L. Cummings & K. Zhong. 2016. Developing Therapeutics for Alzheimer's Disease. Developing Therapeutics for Alzheimer's Disease 459 475 .
Youjun Xu, Ziwei Dai, Fangjin Chen, Shuaishi Gao, Jianfeng Pei & Luhua Lai. (2015) Deep Learning for Drug-Induced Liver Injury. Journal of Chemical Information and Modeling 55:10, pages 2085-2093.
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Albert P. Li. (2015) Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC TM ) System . Toxicological Research 31:2, pages 137-149.
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Jung Woo Eun, Hyun Jin Bae, Qingyu Shen, Se Jin Park, Hyung Seok Kim, Woo Chan Shin, Hee Doo Yang, Chan Young Jin, Jueng Soo You, Hyun Joo Kang, Hoguen Kim, Young Min Ahn, Won Sang Park, Jung Young Lee & Suk Woo Nam. (2015) Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. Journal of Applied Toxicology 35:2, pages 152-164.
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N. Duran-Figueroa, J. A. Badillo-Corona, D. J. Naisbitt & J. L. Castrejon-Flores. (2015) Towards the development of mechanism-based biomarkers to diagnose drug hypersensitivity. Toxicology Research 4:4, pages 777-795.
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Albert P Li. (2014) Biomarkers and human hepatocytes. Biomarkers in Medicine 8:2, pages 173-183.
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Sofie Starckx, Ameesha Batheja, Geert R. Verheyen, Sandra De Jonghe, Kristel Steemans, Bram Van Dijck, Monica Singer, Nancy Bogdan, Jan Snoeys, Petra Vinken, Jennifer C. Sasaki, Jacky Van Gompel, Peggy Guzzie-Peck, Ann Lampo & Lieve Lammens. (2012) Evaluation of miR-122 and Other Biomarkers in Distinct Acute Liver Injury in Rats. Toxicologic Pathology 41:5, pages 795-804.
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Karmen Stankov, Ana Sabo & Momir Mikov. (2013) Pharmacogenetic Biomarkers as Tools for Pharmacoepidemiology of Severe Adverse Drug Reactions. Drug Development Research 74:1, pages 1-14.
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Ann K Daly. (2013) Pharmacogenomics of adverse drug reactions. Genome Medicine 5:1, pages 5.
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Ann K. Daly. (2012) Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions. Annual Review of Pharmacology and Toxicology 52:1, pages 21-35.
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Fuat Ekiz, Ilhami Yüksel, Özlem Ekiz, Şahin Çoban, Ömer Başar & Osman Yüksel. (2011) Levocetirizine induced hepatotoxicity in a patient with chronic urticaria. Annals of Hepatology 10:2, pages 237-238.
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Manmeet S. Padda, Mayra Sanchez, Abbasi J. Akhtar & James L. Boyer. (2011) Drug-induced cholestasis. Hepatology 53:4, pages 1377-1387.
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Harshad Devarbhavi, Ross Dierkhising, Walter K Kremers, M S Sandeep, Dheeraj Karanth & C K Adarsh. (2010) Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality. American Journal of Gastroenterology 105:11, pages 2396-2404.
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João Figueira-Coelho, Olga Pereira, Bárbara Picado, Paula Mendonça, José Neves-Costa & Jorge Neta. (2010) Acute hepatitis associated with the use of levofloxacin. Clinical Therapeutics 32:10, pages 1733-1737.
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John R. Senior. (2009) Unintended Hepatic Adverse Events Associated with Cancer Chemotherapy. Toxicologic Pathology 38:1, pages 142-147.
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