Genetic polymorphism in the Han populations from Shandong province using a novel system based on 41 Y-STRs and 3 Y-InDels

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ABSTRACT

Y chromosome short tandem repeat (Y-STR) within the male-specific part of the human has gained considerable attention in population genetics and forensic investigations. In this study, a novel Y-STR panel developed in-house, which allows co-amplification of 41 Y-STR loci plus 3 Indels in a 6-dye configuration, was used to genotype 74 unrelated Chinese Han males (Shandong, China). A total of 318 alleles could be detected, and the allelic frequencies ranged from 0.0135 to 0.7703. The haplotype diversity and discrimination capacity values were both 1. The gene diversity of 41 Y-STR loci ranged from 0.1037 (DYS645) to 0.9733 (DYS385a/b) in the studied group. The results indicated that the panel possesses high discriminatory capability and exhibits considerable polymorphism in the studied populations.

KEYWORDS:

• Forensic genetics
• 41-plex Y-STR panel
• male identification

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [No. 82002006 and 82030058], Natural Science Foundation of Shandong [No. ZR2022QH337], the Open project of Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science) [KF202206] and the Qingchuang Talents Induction Program of Shandong Higher Education Institution (2022 Forensic medicine innovation team).