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Research Article

Role of Nigella sativa in Preventing Oxidative Stress Damage Using Planaria as Model Organism

Pages 83-95 | Received 07 Aug 2023, Published online: 13 Sep 2023
 

ABSTRACT

Antioxidative effects of N. sativa were explored using planaria as a model organism. Planaria were cultured in water, N. sativa seed extract, hydrogen peroxide, and a combination of hydrogen peroxide and N. sativa. Planaria were decapitated and observed through stages of regeneration. N. sativa treatment increased Planarian growth, locomotion, and protein. Among hydrogen peroxide stress-induced groups, growth was 92% greater, locomotion was 26% higher, and protein was 86% greater when treated with N. sativa. N. sativa accelerated the regeneration of planaria and minimized the effects of stress. N. sativa can be a promising option for preventing neurodegenerative diseases.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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