Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 11
Submit an article Journal homepage
102
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Two new anti-inflammatory compounds from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi

Ping Shaoa Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;b Research and Development Center, NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi, ChinaView further author information
,
Sheng Donga Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Lin-Tong Mua Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Ling Hanb Research and Development Center, NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi, ChinaView further author information
,
Chong-Ning Lva Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaView further author information
,
Jiu-Zhi Yuana Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
View further author information
&
Jin-Cai Lua Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1874-1881 | Received 21 Nov 2022, Accepted 17 Jun 2023, Published online: 03 Jul 2023
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Two new compounds named mandshurica A (1) and mandshurica B (2), together with four known lignans (3–6) were isolated from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi. The structures of the new compounds were elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. Moreover, the anti-inflammatory activity of compounds 1 and 2 were evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compounds 1 and 2 displayed significant inhibitory effect on NO production, and compound 2 exhibited obvious inhibition on the pro-inflammatory cytokines TNF-α. Both new compounds showed potential anti-inflammatory activity.

Graphical Abstract

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by grants from Liaoning Revitalization Talents Program (XLYC1902116), Liaoning provincial science and technology projects (NO. 2022JH1/10800106).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.