Chemical composition and anti-angiogenic activity of the essential oil from Blumea eriantha D.C.

Abstract

Blumea eriantha D.C is a weed from Asteraceae family and is reported to have anticancer activity. The essential oil from the aerial parts was extracted by steam distillation method with the yield of 0.36%. Through GC-MS analysis of the oil, seventeen compounds could be identified by comparing with linear retention indices with the library. Out of the seventeen compounds β-Caryophylline oxide was isolated by column chromatography with gradient elution and the structure was determined through FT-IR, MS, ¹HNMR, ¹³ C NMR and DEPT. The oil was evaluated for its effect on angiogenesis using Chorioallantoic Membrane Assay (CAM Assay). The concentration dependent antiangiogenic effect was observed with IC ₅₀ value of 19.28 ppm.

Graphical Abstract

Keywords:

• Asteraceae
• Blumea eriantha
• essential oil
• β-caryophyllene oxide
• CAM assay

Acknowledgements

The authors are grateful to the Department of Clinical Pharmacology, T.N. Medical College & B.Y.L. Nair Charitable Hospital, Mumbai, India, for helping and utilizing their laboratory facilities to carry out CAM assay.

Disclosure statement

This is to state that the authors do not have any conflict of interests.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.