https://orcid.org/0000-0002-7456-7689
Abstract
Background:
The scope of the study was to analyze original preclinical studies on the antimicrobial effects of carvacrol and derivatives on the Mycobacterium genus.
Materials & methods:
According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, four databases (PubMed, Web of Science, SCOPUS and EMBASE) were searched.
Results:
The search retrieved 392 records, of which 11 papers were selected. Heterogeneity in the techniques and mycobacterial targets was observed. Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis on membranes and biofilms. In silico approaches showed specific targets in mycobacteria, by inhibition and molecular docking assays, on the enzyme chorismate mutase and the heat shock protein 16.3.
Conclusion:
Carvacrol has been shown to be a scaffold candidate for future molecules with activity against mycobacteria.
Tweetable abstract
Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis in specific targets, making it a scaffold candidate for future drugs with activity against mycobacteria.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.4155/fmc-2023-0249
Author contributions
Conceptualization: T Fermiano and R Fressatti Cardoso. Formal analysis: J Perez de Souza, L Murase, J Salvaterra Pasquini. Investigation: J Perez de Souza, L Murase, V Dias Siqueira, K Rizzieri Caleffi-Ferracioli, R de Lima Scodro. Supervision: J Perez de Souza, L Murase and R Fressatti Cardoso. Writing (original draft): J Perez de Souza, L Murase; writing (review and editing): J Meneguello, R Fressatti Cardoso.
Acknowledgments
The authors acknowledge the collaborators of the Laboratory of Medical Bacteriology of the State University of Maringa, the Brazilian Coordination of Superior Level Staff Improvement (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brazil ‘CAPES’) and the Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnologico ‘CNPq’).
Financial disclosure
The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.